Ph.D. Physiology and Biophysics, University of Buffalo, School of Medicine, 2002
M.A. Physiology and Biophysics, University of Buffalo, School of Medicine, 1998
B.S. Biology concentration: Animal Physiology, Cornell University, 1994
Teaching Interests:
Cellular Physiology –This is an upper-level course examining the physiological mechanisms of eukaryotic cells. Topics covered included the cytoskeleton, ion transport, cell signaling pathways and protein expression and regulation.
Neurobiology – This is an upper-level course which will deal with the transmission and mechanisms of neuronal communication. Both the central nervous peripheral nervous systems are investigated, in addition to brain development and higher order function.
Animal Physiology – This is an intermediate to upper-level course discussing systems physiology. In this course the physiological systems of animals will be investigated and examined in terms of structure, function and regulation. A comprehensive view of systems integration is discussed. This course is nicely suited to a pre-professional level student.
General Biology – This is an overview course exploring many topics in biology including the cell, genetics and the evolution of life. This course is geared towards biology and science majors and is complementary to many upper-level biology courses.
Research Interests:
Epithelial cell secretion is important in many physiological processes including airway clearance and digestion. Underlying this secretion is the movement of ions and water into out of the epithelial cells. These regulated ion movements are accomplished through the function of ion channels located a both the apical (lumen) and basolateral (blood) sides of the epithelial cell.
My research focuses on structural and functional studies of a variety of these ion channels which includes: sodium, chloride and potassium channels. Specifically, the calcium-activated potassium and chloride channels are studied; as they have been shown to have an important role in this epithelial cell secretory model. Ion conductance pathways are studied using patch clamp electrophysiology techniques and Ussing® chamber short-circuit current measurements. Ion channel protein expression levels and trafficking is also investigated by combing a variety of cellular and biochemical strategies including: PCR, western blotting and epi-fluorescence.
Publications:
Jones, H.M., Bailey, M.A., Baty, C.J. MacGregor, G.G., Syme, C.A., Bailey, M.A., Hamilton, K.L. and D.C. Devor. Nov. 2006. An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1. (Submitted) Journal of General Physiology, London.
Jones, H.M., Hamilton, K.L., Devor, D.C. 2005. Role of an S4-S5 linker lysine in the trafficking of the Ca2+-activated K+ channels IK1 and SK3. J Biol Chem. Nov 4; 280(44):37257-65.
Jones, H.M., Watkins, S.C., Bradbury, N. A., and D.C. Devor. 2003. Multiple leucine motifs in the NH2-terminus of hIK1 are important in channel assembly and trafficking. J Biol Chem 279 (15):15531-40.
Syme, C.A., Hamilton, K.L., Jones, H.M., Gerlach A.C., Giltinan, L., Watkins, S.C., Bradbury, N.A., D.C. Devor. 2003. Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. J Biol Chem 278 (10): 8476-86.
Crane, J.K., R.A. Olsen, H.M. Jones, and M.E. Duffey. 2002. Release of Adenosine Triphosphate (ATP) During host cell killing by enteropathogenic Escherichia Coli and its role as a secretory mediator. Am J Physiol Gastrointest Liver Physiol Jul;283(1):G74-G86.
Interested persons can reach me for information at:
Phone: 814-898-6619
email: hmj10@psu.edu
This page was last updated 16 Feb 2006 .